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Differential Expression Of Vascular Dysfunction Of Smaller Diameter Arteries In A Rodent Model Of Metabolic Syndrome by Ibrahim Salman; Omar Ameer; Aiman Alwadi is a Medicine article available to read on EtoBox.

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Objective: Afferent nerve pathways form kidney and heart are said to control sympathetic renal nerve activity. In a renal disease model the responsiveness of afferent renal nerve units was shifted from units with highly active primary neurons (tonic response pattern) to units with neurons of very low activity upon stimulation (phasic response pattern). Afferent renal nerve activity was likely decreased. Likewise, afferent vagal nerve activity in congestive heart failure (CHF) had a lower frequency at saturation than controls. Hence we wanted to test the hypothesis that CHF the vagal afferent nerve pathway consists of a decreased number of highly active tonic sensory neurons in the nodose ganglion. Design and method: CHF was induced by coronary artery ligature, nephropathy by injections of an anti Thy1.1 antibody (OX7, 1.2 mg/kg). After a respective time (CHF 21 days, nephropathy 7 days after induction) nodose ganglion neurons with cardiac vagal afferents from CHF rats or neurons form dorsal root ganglia with renal afferents from rats with nephropathy were cultured. Current clamp was used to characterize neurons as tonic, i.e. sustained action potential (AP) fi ring or phasict, i.e.

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Author

Ibrahim Salman; Omar Ameer; Aiman Alwadi

Publisher

Ovid Technologies (Wolters Kluwer Health)

Published

2021

Language

EN

Field

Medicine (Health Sciences)