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Bredeldin A by phamquocdoanh0510 is a document available to read on EtoBox.
What is Bredeldin A about?
The document details the total synthesis of (+)-brefeldin A achieved through 15 linear steps with a 7.9% overall yield, starting from a known Weinreb amide. Key aspects of the synthesis include the stereoselective construction of the hydroxycyclopentane skeleton and the introduction of the acrylate moiety using a new acyl anion equivalent. The synthesis aims to provide a practical and versatile route for the production of brefeldin A and its analogues, which have significant biological activities.
- Author
- phamquocdoanh0510
- Language
- EN