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Synthesis and pharmacological evaluation of 1,1,3-substituted urea derivatives as potent TNF-α production inhibitors by Hiroshi Enomoto; Ayako Sawa; Hiroshi Suhara; Noriyoshi Yamamoto; Hiroyuki Inoue; Chikako Setoguchi; Fumio Tsuji; Masahiro Okamoto; Yoshimasa Sasabuchi; Masato Horiuchi; Masakazu Ban is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and pharmacological evaluation of 1,1,3-substituted urea derivatives as potent TNF-α production inhibitors about?
A three substituted urea derivative, SA13353 (compound 1a), exhibited potent inhibitory activity against lipopolysaccharide (LPS)-induced TNF-alpha production. We focused on the 1,1-substituted moiety (R(1) and R(2)) of SA13353 and investigated substituent effects of this moiety on LPS-induced TNF-alpha production by oral administration in rats. The synthesis of the urea derivatives was performed rapidly in a one-pot manner using a manual synthesizer. Several compounds containing hydrophobic substituents at this moiety showed more potent inhibitory activities than SA13353.
Who reads Synthesis and pharmacological evaluation of 1,1,3-substituted urea derivatives as potent TNF-α production inhibitors?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Hiroshi Enomoto; Ayako Sawa; Hiroshi Suhara; Noriyoshi Yamamoto; Hiroyuki Inoue; Chikako Setoguchi; Fumio Tsuji; Masahiro Okamoto; Yoshimasa Sasabuchi; Masato Horiuchi; Masakazu Ban
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)