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Antiviral activity of glycyrrhizic acid conjugates with amino acid esters against Zika virus by Lidia A. Baltina; Mann-Jen Hour; Ya-Chi Liu; Young-Sheng Chang; Su-Hua Huang; Hsueh-Chou Lai; Rimma M. Kondratenko; Svetlana F. Petrova; Marat S. Yunusov; Cheng-Wen Lin is a Medicine article available to read on EtoBox.
What is Antiviral activity of glycyrrhizic acid conjugates with amino acid esters against Zika virus about?
Zika virus (ZIKV) is a new pathogenic flavivirus transmitted by mosquitoes Aedes spp. ZIKV infection is accompanied by serious neurological complications and is especially dangerous for pregnant women, in which it can lead to congenital malformations of the fetus and microcephaly in neonates. Currently, there are no licensed vaccines or specific post-infectious therapies for ZIKV infection. This report is devoted to the study of glycyrrhizic acid (GL) derivatives as ZIKV inhibitors. The inhibitory assays on the cytopathic effect (CPE) and viral infectivity of ZIKV in three different human cell lines revealed that the conjugation of GL with amino acids and their esters (methyl, ethyl) is influenced by the antiviral activity of the compounds. GL conjugates with Glu(OMe)-OMe 11, Glu(OH)-OMe 12, Asp(OMe)-OMe 13, TyrOMe 14, LeuOEt 15, and PheOEt 16 with free COOH groups in the triterpene moiety were active against ZIKV. The most active compounds 13 and 14 have IC50 values of 0.23 μM and 0.09 μM against low doses (MOI = 0.05) of ZIKV strain PRVABC59, 1.20 μM and 0.74 μM against high doses (MOI = 10) of ZIKV strain Natal RGN single-round infectious particles, respectively. The lead compou
Who reads Antiviral activity of glycyrrhizic acid conjugates with amino acid esters against Zika virus?
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- Author
- Lidia A. Baltina; Mann-Jen Hour; Ya-Chi Liu; Young-Sheng Chang; Su-Hua Huang; Hsueh-Chou Lai; Rimma M. Kondratenko; Svetlana F. Petrova; Marat S. Yunusov; Cheng-Wen Lin
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)