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A Method of Analysis of Cellular Distribution in the Membrane Encapsulating Surgically Implanted Biomaterials by P. Christel; A. Meunier; M. Therin is a Medicine article available to read on EtoBox.

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This article describes a method for analyzing the cell distribution occurring in the membrane encapsulating cylinders of specific polymers, metals, or ceramics when implanted in the paraspinal muscles in rats for periods between 2 weeks and 1 year. Using a computerassisted cell-counting method, it is shown that the cell distribution exhibits a non-Gaussian spectrum, which can be modeled by a three-parameter statistical function. This observation was made possible because of the use of specific histological techniques, adapted to each particular material class, (polymer, metal, ceramic), keeping intact the implant-tissue interface. The parameters arising from the histomorphometric and statistical analyses allow comprehensive and quantitative comparisons of the tissue response induced by the various implanted materials. This pattern of cell distribution was observed with all of the implanted materials to one year. This behavior has also been observed in rabbit muscle and reported by others in subcutaneous tissue in mice. This method provides both a way to evaluate the tissue response to a surgically implanted material on a quantitative basis and a research tool for the study of tissu

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Author

P. Christel; A. Meunier; M. Therin

Publisher

Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1045-4861)

Published

1990

Language

EN

Field

Medicine (Health Sciences)