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Elevated Carcinoembryonic Antigen Levels Correlating with Disease Recurrence in a Patient with Adenoid Cystic Carcinoma by Dr. William I. Kuhel; Dr. Harold Chow; Dr. Thomas A. Godwin; Dr. C. Richard Minick; Dr. Daniel M. Libby is a scholarly article available to read on EtoBox.

What is Elevated Carcinoembryonic Antigen Levels Correlating with Disease Recurrence in a Patient with Adenoid Cystic Carcinoma about?

Background. Carcinoembryonic antigen (CEA) is an oncofetal glycoprotein involved in cell recognition and adhesion. Serum CEA has been extensively studied as a potential chemical marker for malignancy, most notably in patients with colon carcinoma. Serum CEA measurements have not been reported for patients with salivary gland carcinomas. Methods. Serum CEA was measured in a case study using enzyme immunoassay with monoclonal antibody specific for CEA. Tissue was examined with standard histologic and immunohistologic methods. Results. A patient was initially seen with adenoid cystic carcinoma (ACC) of the trachea and had a markedly elevated serum CEA level which declined after surgical resection. The serum CEA level became elevated again when the patient developed abdominal metastases and then declined after debulking of the tumor. lmmunohistochemical study of the tumor was positive for CEA. Conclusions. The measurement of serum CEA levels may play a role in the management of patients with ACC. Clinical investigation utilizing monoclonal antibodies against CEA, for imaging and for the delivery of chemotherapy and radiotherapy may be worthwhile.

Author

Dr. William I. Kuhel; Dr. Harold Chow; Dr. Thomas A. Godwin; Dr. C. Richard Minick; Dr. Daniel M. Libby

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1043-3074)

Published

1995

Language

EN