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What is Cumene Carcinogenicity in ICH Q3C Guidelines about?

1) New toxicity data shows that cumene, a Class 3 solvent with low toxicity, is carcinogenic. Studies found cumene caused nasal and lung cancer in rats and mice. 2) The International Conference on Harmonisation (ICH) will form an expert working group to revise the ICH Q3C guideline on residual solvents. This is needed to account for the new toxicity data related to cumene. 3) The working group will comprise experts nominated by ICH sponsors and industry groups. They will review the permissible daily expo

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chemtab

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EN