Opening book details…
Can I read Up-regulation of extracellular matrix proteoglycans and collagen type I in human crescentic glomerulonephritis on EtoBox?
Up-regulation of extracellular matrix proteoglycans and collagen type I in human crescentic glomerulonephritis by Stokes, Michael B.; Hudkins, Kelly L.; Zaharia, Valentin; Taneda, Sekiko; Alpers, Charles E. is a Medicine article available to read on EtoBox.
What is Up-regulation of extracellular matrix proteoglycans and collagen type I in human crescentic glomerulonephritis about?
## Background: The pathogenesis of crescentic glomerulonephritis (cgn) involves cellular migration and proliferation in the urinary space, frequently followed by fibrous organization. extracellular matrix proteoglycans (pgs) may regulate these events via effects on cellular migration, interactions with growth factors, including transforming growth factor-beta (tgf-beta), and control of collagen fibrillogenesis. the expression of pg in human cgn is unknown. ## Methods: Renal tissues from 18 patients with cgn were examined immunohistochemically for versican, decorin, biglycan and collagen type i, and were compared with morphologically normal tissues from six tumor nephrectomies. synthesis of decorin, biglycan, and procollagen type i mrnas was evaluated by in situ hybridization. ## Results: Versican was strongly expressed in cellular crescents and periglomerular areas, whereas decorin and biglycan accumulated in collagen type i-enriched regions, including fibrocellular and fibrous crescents, and interstitial fibrosis. pg and collagen type i accumulation colocalized with myofibroblasts in crescents, periglomerular areas, and interstitium. ## Conclusions: The temporal and spatial patter
Who reads Up-regulation of extracellular matrix proteoglycans and collagen type I in human crescentic glomerulonephritis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Stokes, Michael B.; Hudkins, Kelly L.; Zaharia, Valentin; Taneda, Sekiko; Alpers, Charles E.
- Publisher
- Nature Publishing Group; Elsevier ; Elsevier Inc.; Elsevier BV; ScienceOpen (ISSN 0085-2538)
- Published
- 2001
- Language
- EN
- Field
- Medicine (Health Sciences)