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Analysis of Hemisphere-dependent Effects of Unilateral Intrastriatal Injection of α-Synuclein Pre-formed Fibrils on Mitochondrial Protein Levels, Dynamics, and Function by Rose B. Creed; Adeel A. Memon; Sindhu P. Komaragiri; Sandeep K. Barodia; Matthew S. Goldberg is a Medicine article available to read on EtoBox.
What is Analysis of Hemisphere-dependent Effects of Unilateral Intrastriatal Injection of α-Synuclein Pre-formed Fibrils on Mitochondrial Protein Levels, Dynamics, and Function about?
Genetic and neuropathological evidence strongly implicates aberrant forms of α-synuclein in neurodegeneration. Antibodies specific for α-synuclein phosphorylated at serine 129 (pS129) are selective for the pathological protein aggregates that are characteristic of Parkinson’s disease (PD) and other synucleinopathies, such as dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). Although the etiology of most synucleinopathies remains uncertain, a large body of evidence points to mitochondrial dysfunction. The recent development of animal models based on intracranial injection of α-synuclein pre-formed fibrils (PFFs) has provided a valuable experimental system in which to study the spread and neurotoxicity of α-synuclein aggregates, yet the effects of PFF-induced protein aggregates on mitochondrial function and dynamics have not been rigorously examined in vivo. To help fill this knowledge gap, we injected the striatum of mice unilaterally with well-characterized small length (< 30 nm) PFFs or monomeric α-synuclein control and measured the distribution and extent of pS129 α-synuclein-immunoreactive aggregates, the loss of tyrosine hydroxylase-immunoreactive neurons in th
Who reads Analysis of Hemisphere-dependent Effects of Unilateral Intrastriatal Injection of α-Synuclein Pre-formed Fibrils on Mitochondrial Protein Levels, Dynamics, and Function?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Rose B. Creed; Adeel A. Memon; Sindhu P. Komaragiri; Sandeep K. Barodia; Matthew S. Goldberg
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)