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MicroRNA miR-155 is required for expansion of regulatory T cells to mediate robust pregnancy tolerance in mice by John E. Schjenken; Lachlan M. Moldenhauer; Bihong Zhang; Alison S. Care; Holly M. Groome; Hon-Yeung Chan; Christopher M. Hope; Simon C. Barry; Sarah A. Robertson is a Immunology and Microbiology article available to read on EtoBox.
What is MicroRNA miR-155 is required for expansion of regulatory T cells to mediate robust pregnancy tolerance in mice about?
The immune-regulatory microRNA miR-155 is reduced in recurrent miscarriage, suggesting that miR-155 contributes to immune tolerance in pregnancy. Here we show miR-155 is induced in the uterine mucosa and draining lymph nodes (dLN) during the female immune response to male seminal fluid alloantigens. Mice with null mutation in miR-155 (miR-155 −/− ) exhibited a reduced CD4 + T cell response after mating, with a disproportionate loss of CD25+FOXP3+ Treg cells. miR-155 deficiency impaired expansion of both peripheral and thymic Treg cells, distinguished by neuropilin-1 (NRP1), and fewer Treg cells expressed Ki67 proliferation marker and suppressive function marker CTLA4. Altered Treg phenotype distribution in miR-155 −/− mice was confirmed by t-distributed neighbor embedding (tSNE) analysis. Fewer dendritic cells (DCs) and macrophages trafficked to the dLN of miR-155 −/− mice, associated with lower CCR7 on DCs, and reduced uterine Ccl19 expression, implicating compromised antigen presentation in the stunted Treg cell response. miR-155 −/− mice exhibited elevated susceptibility to inflammation-induced fetal loss and fetal growth restriction compared with miR-155 +/+ controls, but outco
Who reads MicroRNA miR-155 is required for expansion of regulatory T cells to mediate robust pregnancy tolerance in mice?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- John E. Schjenken; Lachlan M. Moldenhauer; Bihong Zhang; Alison S. Care; Holly M. Groome; Hon-Yeung Chan; Christopher M. Hope; Simon C. Barry; Sarah A. Robertson
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)