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Proximal Versus Distal Diuretics in Congestive Heart Failure by Nardone Massimo, Sridhar Vikas S., Yau Kevin, Odutayo Ayodele, Cherney David Z. I. is a book available to read on EtoBox.

What is Proximal Versus Distal Diuretics in Congestive Heart Failure about?

DOI: 10.1093/ndt/gfae058 Nephrology Dialysis Transplantation, 0, 0, 29-02-2024. Abstract: Volume overload represents a hallmark clinical feature linked to the development and progression of heart failure (HF). Alleviating signs and symptoms of volume overload represents a foundational HF treatment target that is achieved using loop diuretics in the acute and chronic setting. Recent work has provided evidence to support guideline-directed medical therapies, such as sodium glucose cotransporter 2 (SGLT2) inhibitors and mineralocorticoid receptor (MR) antagonists, as important adjunct diuretics that may act synergistically when used with background loop diuretics in people with chronic HF. Furthermore, there is growing interest in understanding the role of SGLT2 inhibitors, carbonic anhydrase inhibitors, thiazide diuretics, and MR antagonists in treating volume overload in patients hospitalized for acute HF, particularly in the setting of loop diuretic resistance. Thus, the current review demonstrates that: (i) SGLT2 inhibitors and MR antagonists confer long-term cardioprotection in chronic HF patients but it is unclear whether natriuresis or diuresis represents the primary mechanisms

Author

Nardone Massimo, Sridhar Vikas S., Yau Kevin, Odutayo Ayodele, Cherney David Z. I.

Publisher

Oxford University Press

Published

2024

Language

EN