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FGF signaling is required for chemokinesis and ventral migration of trunk neural crest cells by Haley Dunkel; Martha Chaverra; Roger Bradley; Frances Lefcort is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is FGF signaling is required for chemokinesis and ventral migration of trunk neural crest cells about?

## Abstract ## Background Neural crest cells (NCCs) delaminate from the neural tube (NT) and migrate ventrally to generate the trunk peripheral nervous system (PNS). Although several signaling pathways have been identified that steer NCCs once they are on their ventral trajectory, no molecules have been identified that are required for the initial migration between the NT and the dorsal root ganglion. Given the critical role of fibroblast growth factor (FGF) signaling in embryogenesis, we investigated its function in this initial migration. ## Results FGFR1 signaling is required for the migration of newly delaminated NCCs onto the ventral pathway. Live imaging of migrating NCCs revealed that inhibition of FGFR1 signaling caused the dorsally stalled NCCs to lose their dorsal/ventral oriented polarity and instead adopt a rounded morphology while dynamically extending filopodia. FGF8, an FGFR1 ligand, increased motility of NCCs away from the NT by acting chemokinetically. Finally, we provide evidence that inhibition of FGFR1‐mediated chemokinesis is partially rescued by increasing Akt signaling, inhibiting RhoA, and activation of N‐cadherin signaling. ## Conclusion These data support

Who reads FGF signaling is required for chemokinesis and ventral migration of trunk neural crest cells?

Author

Haley Dunkel; Martha Chaverra; Roger Bradley; Frances Lefcort

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1058-8388)

Published

2020

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)