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Mortality and causes of death in primary Sjögren's syndrome: A prospective cohort study by Elke Theander; Rolf Manthorpe; Lennart T. H. Jacobsson is a Medicine article available to read on EtoBox.

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## Objective: This study was undertaken to analyze standardized mortality ratios (smrs) and causes and predictors of death in primary sjögren's syndrome (ss) diagnosed according to 3 different classification criteria sets (the copenhagen criteria, the european criteria, and the american-european consensus criteria (aecc). ## Methods: A linked registry study using information from the malmö primary ss registry combined with the swedish cause-of-death registry was performed, and smrs were calculated. kaplan-meier survival curves and log rank tests were used to compare survival probability between subgroups of patients with primary ss. cox regression analysis was used to study the predictive value of various laboratory findings at the time of diagnosis. ## Results: Four hundred eighty-four patients with a median followup of 7 years (range 1 month to 17 years 11 months) were included. the smr for those fulfilling the aecc (n = 265) was 1.17 (95% confidence interval [95% ci] 0.81-1.63). thirty-four deaths occurred in this group of patients. excess mortality was found only for lymphoproliferative malignancy (cause-specific smr 7.89 [95% ci 2.89-17.18]), corresponding to 2.53 excess death

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Author

Elke Theander; Rolf Manthorpe; Lennart T. H. Jacobsson

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0004-3591)

Published

2004

Language

EN

Field

Medicine (Health Sciences)