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Chronic Alcoholism Enhances Hepatocarcinogenicity of Diethylnitrosamine in Rats Fed a Marginally Methyl-deficient Diet by Eduardo A. Porta; Nalani Markell; Russell D. Dorado is a Medicine article available to read on EtoBox.

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To determine whether the chronic consumption of ethanol was capable of enhancing the hepatocarcinogenic activity of diethylnitrosamine per se, or through the accentuation of a methyl deficiency, two groups (A and B) of Sprague-Dawley female rats were fed for 10 months either a 20% casein basal diet marginally deficient in methyl, or the same diet supplemented with choline (1 gm per 100 gm) and folic acid (0.54 mg per 100 gm). Both g r o u p were offered a drinking ethanol solution, while two other nonalcohol control g r o u p (C and D) were isocalorically pair-fed to Groups A and B, and received diets in which the alcohol consumed by the corresponding g r o u p was replaced by h a l o r i c amounts of sucrose. A baseline nonalcohol Group E, ieocalorically pairfed to Group A, received the intact basal diet of Group A and water. One day before the initiation of the experiment, and again 2 months later, all rats from the five groups were injected with a single i.p. dose of diethylnitrosamine (100 mg per kg). The growth attained by all groups was statisticlly similar. Hepatic triglycerides in Group A were significantly higher than in all the other groups. While in Group A primary hepat

Who reads Chronic Alcoholism Enhances Hepatocarcinogenicity of Diethylnitrosamine in Rats Fed a Marginally Methyl-deficient Diet?

Author

Eduardo A. Porta; Nalani Markell; Russell D. Dorado

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Elsevier BV; Wiley; Research Square (ISSN 0270-9139)

Published

1985

Language

EN

Field

Medicine (Health Sciences)