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Critical investigation of coupled liquid chromatography–NMR spectroscopy in pharmaceutical impurity identification by Gary J. Sharman; Ian C. Jones is a Chemistry article available to read on EtoBox.
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## Abstract In this paper, we investigate the application of coupled LC–NMR to the identification of low‐level impurities. We consider the absolute sensitivity of the technique with our instrumentation, and how this is degraded by peak broadening on and after column, and we compare the sensitivity and other aspects of LC–NMR with a more classical approach of impurity isolation and tube NMR. We show that despite the undoubted advantages of LC–NMR in many situations, for the identification of very low‐level impurities it may not always be the most efficient overall approach when all factors are considered. Copyright © 2003 John Wiley & Sons, Ltd.
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It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Gary J. Sharman; Ian C. Jones
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; John Wiley and Sons Ltd; Wiley (ISSN 0749-1581)
- Published
- 2003
- Language
- EN
- Field
- Chemistry (Physical Sciences)