Can I read Oral Administration of Olaquindox Negatively Affects Oocytes Quality and Reproductive Ability in Female Mice on EtoBox?

Oral Administration of Olaquindox Negatively Affects Oocytes Quality and Reproductive Ability in Female Mice by Yu-Qing Gao; Lei Ge; Zhe Han; Xin Hao; Mei-Ling Zhang; Xiao-Jie Zhang; Cheng-Jie Zhou; De-Jian Zhang; Cheng-Guang Liang is a Environmental Science article available to read on EtoBox.

What is Oral Administration of Olaquindox Negatively Affects Oocytes Quality and Reproductive Ability in Female Mice about?

As an effective feed additive in the livestock industry, olaquindox (OLA) has been widely used in domestic animal production. However, it is unclear whether OLA has negative effects on mammalian oocyte quality and fetal development. In this study, toxic effects of OLA were tested by intragastric gavage ICR mice with water, low-dose OLA (5 mg/kg/day), or high-dose OLA (60 mg/kg/day) for continuous 45 days. Results showed that high-dose OLA gavage severely affected the offspring birth and growth. Significantly, high-dose OLA impaired oocyte maturation and early embryo development, indicated by the decreased percentage of germinal vesicle breakdown, first polar body extrusion and blastocyst formation. Meanwhile, oxidative stress levels were increased in oocytes or ovaries, indexed by the increased levels of ROS, MDA, HO, NO, and decreased levels of GSH, SOD, CAT, GSH-Px and GSH-Rd. Furthermore, aberrant mitochondria distribution, defective spindle assembly, abnormal H3K4me2/H3K9me3 levels, increased DNA double-strand breaks and early apoptosis rate, were observed after high-dose OLA gavage. Taken together, our results for the first time illustrated that high-dose OLA gavage led to sub

Who reads Oral Administration of Olaquindox Negatively Affects Oocytes Quality and Reproductive Ability in Female Mice?

Author

Yu-Qing Gao; Lei Ge; Zhe Han; Xin Hao; Mei-Ling Zhang; Xiao-Jie Zhang; Cheng-Jie Zhou; De-Jian Zhang; Cheng-Guang Liang

Publisher

Elsevier BV

Published

2020

Language

EN

Field

Environmental Science (Physical Sciences)