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Synthesis of [^11^C]levofloxacin by M. S. Berridge; E. M. Burnazi is a Chemistry article available to read on EtoBox.
What is Synthesis of [^11^C]levofloxacin about?
## Abstract Levofloxacin, the pure S enantiomer of the fluoroquinolone antibiotic ofloxacin, was labeled via methylation of the corresponding, __des__‐methyl, secondary amine with N.C.A. [^11^C]methyl iodide. The methylation reaction was regioselective, giving predominantly the preferred methyl amine at high temperature in DMF, while otherwise giving predominantly the methyl ester of a free carboxylic acid also present in the molecule. Levofloxacin was obtained in 80% chemical yield after a 45 min synthesis. Copyright © 2001 John Wiley & Sons, Ltd.
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- Author
- M. S. Berridge; E. M. Burnazi
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-2135)
- Published
- 2001
- Language
- EN
- Field
- Chemistry (Life Sciences)