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On Diabetic Foot Ulcer Knowledge Gaps, Innovation, Evaluation, Prediction Markers, and Clinical Needs by Brian M. Schmidt; Crystal M. Holmes; Kayvan Najarian; Katherine Gallagher; Jacob M. Haus; James Shadiow; Wen Ye; Lynn Ang; Aaron Burant; Nicole Baker; Aimee Katona; Catherine L. Martin; Rodica Pop-Busui is a scholarly article available to read on EtoBox.

What is On Diabetic Foot Ulcer Knowledge Gaps, Innovation, Evaluation, Prediction Markers, and Clinical Needs about?

A C T Diabetic foot ulcers (DFUs) remain a very prevalent and challenging complication of diabetes worldwide due to high morbidity, high risks of lower extremity amputation and associated mortality. Despite major advances in diabetes treatment in general, there is a paucity of FDA approved technologies and therapies to promote successful healing. Furthermore, accurate biomarkers to identify patients at risk of non-healing and monitor response-to-therapy are significantly lacking. To date, research has been slowed by a lack of coordinated efforts among basic scientists and clinical researchers and confounded by non-standardized heterogenous collection of biospecimen and patient associated data. Novel technologies, especially those in the single and 'multiomics' arena, are being used to advance the study of diabetic foot ulcers but require pragmatic study design to ensure broad adoption following validation. These high throughput analyses offer promise to investigate potential biomarkers across wound trajectories and may support information on wound healing and pathophysiology not previously well understood. Additionally, these biomarkers may be used at the point-of-care. In combinat

Author

Brian M. Schmidt; Crystal M. Holmes; Kayvan Najarian; Katherine Gallagher; Jacob M. Haus; James Shadiow; Wen Ye; Lynn Ang; Aaron Burant; Nicole Baker; Aimee Katona; Catherine L. Martin; Rodica Pop-Busui

Publisher

Elsevier BV

Published

2022

Language

EN