Can I read Clostridium Difficile Cell-surface Polysaccharides Composed of Pentaglycosyl and Hexaglycosyl Phosphate Repeating Units on EtoBox?

Clostridium Difficile Cell-surface Polysaccharides Composed of Pentaglycosyl and Hexaglycosyl Phosphate Repeating Units by Jeyabarathy Ganeshapillai; Evguenii Vinogradov; Joyce Rousseau; J. Scott Weese; Mario A. Monteiro is a scholarly article available to read on EtoBox.

What is Clostridium Difficile Cell-surface Polysaccharides Composed of Pentaglycosyl and Hexaglycosyl Phosphate Repeating Units about?

Clostridium difficile is a Gram-positive bacterium that is known to be a cause of enteric diseases in humans. It is the leading cause of antibiotic-associated diarrhea and pseudomembranous colitis. Recently, large outbreaks of C. difficile-associated diarrhea have been reported internationally, and there have been reports of increases in severe disease, mortality and relapse rates. At the moment, there is no vaccine against C. difficile, and the medical prevention of C. difficile infection is mostly based on the prophylactic use of antibiotics; however, this has led to an increase in the incidence of the disease. Here, we describe the chemical structure of C. difficile cell-surface polysaccharides. The polysaccharides of three C. difficile strains were structurally analyzed; ribotype 027 (North American pulsotype 1) strain was observed to express two polysaccharides, one was composed of a branched pentaglycosyl phosphate repeating unit: [?4)-a-L L-Rhap-(1?3)-b-D D-Glcp-(1?4)-[a-L L-Rhap-(1?3]-a-D D-Glcp-(1?2)-a-D D-Glcp-(1?P] and the other was composed of a hexaglycosyl phosphate repeating unit: [?6)-b-D D-Glcp-(1?3)-b-D D-GalpNAc-(1?4)-a-D D-Glcp- (1?4)-[b-D D-Glcp-(1?]-b-D D-Galp

Author

Jeyabarathy Ganeshapillai; Evguenii Vinogradov; Joyce Rousseau; J. Scott Weese; Mario A. Monteiro

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0008-6215)

Published

2008

Language

EN