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Can I read Bioenergetics: the Evolutionary Basis of Progressive Kidney Disease on EtoBox?
Bioenergetics: the Evolutionary Basis of Progressive Kidney Disease by Robert L. Chevalier is a Medicine article available to read on EtoBox.
What is Bioenergetics: the Evolutionary Basis of Progressive Kidney Disease about?
Chronic kidney disease (CKD) affects >10% of the world population, with increasing prevalence in middle age. The risk for CKD is dependent on the number of functioning nephrons through the life cycle, and 50% of nephrons are lost through normal aging, revealing their vulnerability to internal and external stressors. Factors responsible for CKD remain poorly understood, with limited availability of biomarkers or effective therapy to slow progression. This review draws on the disciplines of evolutionary medicine and bioenergetics to account for the heterogeneous nephron injury that characterizes progressive CKD following episodes of acute kidney injury with incomplete recovery. The evolution of symbiosis in eukaryotes led to the efficiencies of oxidative phosphorylation and the rise of metazoa. Adaptations to ancestral environments are the products of natural selection that have shaped the mammalian nephron with its vulnerabilities to ischemic, hypoxic, and toxic injury. Reproductive fitness rather than longevity has served as the driver of evolution, constrained by available energy and its allocation to homeostatic responses through the life cycle. Metabolic plasticity has evolved i
Who reads Bioenergetics: the Evolutionary Basis of Progressive Kidney Disease?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Robert L. Chevalier
- Publisher
- American Physiological Society
- Published
- 2023
- Language
- EN
- Field
- Medicine (Life Sciences)