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Can I read Penile bacteria associated with HIV seroconversion, inflammation, and immune cells on EtoBox?
Penile bacteria associated with HIV seroconversion, inflammation, and immune cells by Jessica L. Prodger; Alison G. Abraham; Aaron A.R. Tobian; Daniel E. Park; Maliha Aziz; Kelsey Roach; Ronald H. Gray; Lane Buchanan; Godfrey Kigozi; Ronald M. Galiwango; Joseph Ssekasanvu; James Nnamutete; Joseph Kagaayi; Rupert Kaul; Cindy M. Liu is a Immunology and Microbiology article available to read on EtoBox.
What is Penile bacteria associated with HIV seroconversion, inflammation, and immune cells about?
The foreskin is a site of heterosexual acquisition of HIV-1 among uncircumcised men. However, some men remain HIV-negative despite repeated, unprotected vaginal intercourse with HIV-positive partners, while others become infected after few exposures. The foreskin microbiome includes a diverse group of anaerobic bacteria that have been linked to HIV acquisition. However, these anaerobes tend to coassociate, making it difficult to determine which species might increase HIV risk and which may be innocent bystanders. Here, we show that 6 specific anaerobic bacterial species, __Peptostreptococcus anaerobius__, __Prevotella bivia__, __Prevotella disiens__, __Dialister propionicifaciens__, __Dialister micraerophilus__, and a genetic near neighbor of __Dialister succinatiphilus__, significantly increased cytokine production, recruited HIV-susceptible CD4^+^ T cells to the inner foreskin, and were associated with HIV acquisition. This strongly suggests that the penile microbiome increases host susceptibility to HIV and that these species are potential targets for microbiome-based prevention strategies.
Who reads Penile bacteria associated with HIV seroconversion, inflammation, and immune cells?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Jessica L. Prodger; Alison G. Abraham; Aaron A.R. Tobian; Daniel E. Park; Maliha Aziz; Kelsey Roach; Ronald H. Gray; Lane Buchanan; Godfrey Kigozi; Ronald M. Galiwango; Joseph Ssekasanvu; James Nnamutete; Joseph Kagaayi; Rupert Kaul; Cindy M. Liu
- Publisher
- American Society for Clinical Investigation
- Published
- 2021
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)