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What is Local Opioid Analgesia in Infant Rats about?

This study examined the analgesic effects of locally injecting opioid receptor agonists into the paws of infant rats in a formalin pain test. The study found: 1) The kappa opioid receptor agonist U50,488 reduced pain behavior and spinal cord Fos expression at both 3 and 21 days of age, demonstrating kappa receptor mediated analgesia in neonates. 2) The mu opioid agonist morphiceptin reduced pain only at 21 days, not 3 days, showing mu receptor analgesia develops later. 3) The delta opioid agonist DPDPE

Author

Jéssica Vaz

Language

EN