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Can I read Expression of human and mouse genes encoding polκ: testis‐specific developmental regulation and AhR‐dependent inducible transcription on EtoBox?
Expression of human and mouse genes encoding polκ: testis‐specific developmental regulation and AhR‐dependent inducible transcription by Tomoo Ogi; Junsei Mimura; Masaki Hikida; Hirokazu Fujimoto; Yoshiaki Fujii‐Kuriyama; Haruo Ohmori is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Expression of human and mouse genes encoding polκ: testis‐specific developmental regulation and AhR‐dependent inducible transcription about?
**Backgrounds** Human polκ is a newly identified low‐fidelity DNA polymerase. While the enzyme bypasses an abasic site and acetylaminofluorene‐adduct in an error‐prone manner, it bypasses benzo[__a__]pyrene‐N2‐dG lesions in a mostly error‐free manner by incorporating predominantly dC opposite the bulky lesions. Benzo[__a__]pyrene (B[__a__]P) is activated through intracellular process mediated by the arylhydrocarbon receptor (AhR, also called the dioxin receptor), which is a ligand‐activated transcription factor with high affinities for aromatic compounds such as B[__a__]P and dioxin. **Results** We examined promoter structures of the human __POLK__ and mouse __Polk__ genes to study how their expressions are regulated. The mouse __Polk__ gene is developmentally regulated in testis and utilizes two transcription start sites during spermatogenesis, while it utilizes only one site in tissues other than testis. Both of the mouse __Polk__ and the human __POLK__ genes have two AhR‐binding sites in the promoter regions and the expression of the mouse __Polk__ gene is indeed enhanced upon AhR‐activation. **Conclusions** The AhR activation increases expression of the mouse __Polk__ gene and
Who reads Expression of human and mouse genes encoding polκ: testis‐specific developmental regulation and AhR‐dependent inducible transcription?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Tomoo Ogi; Junsei Mimura; Masaki Hikida; Hirokazu Fujimoto; Yoshiaki Fujii‐Kuriyama; Haruo Ohmori
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 1356-9597)
- Published
- 2001
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)