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Carbamates and ureas derived from 11-amino-6,11-dihydrodibenzo[b,e]thiepin; Synthesis and pharmacological screening by Vladimír Valenta, Marie Bartošová and Miroslav Protiva is a scholarly article available to read on EtoBox.

What is Carbamates and ureas derived from 11-amino-6,11-dihydrodibenzo[b,e]thiepin; Synthesis and pharmacological screening about?

A series of N-substituted carbamates V-XIII was prepared by reactions of 6,11-dihydrodibenzo[b,e]thiepin-11-ol (I) with carbamates H2NCOOR in acetic acid. Whereas the Leuckart reaction of dibenzo[b,e]thiepin-11(6H)-one yielded 9-formamido-10-methylene-9,10-dihydroanthracene (XVIII), a satisfactory method for preparing the amine III was found in heating the carbamate V with 2-aminoethanol to 170°C. Reactions of the amine III with isocyanates gave most of the disubstituted ureas XX-XXV. The expected anticonvulsant activity was found only in high doses with compounds IX, XII, XV, XX, XXI and XXXIII.

Author

Vladimír Valenta, Marie Bartošová and Miroslav Protiva

Published

1980

Language

EN