Can I read Stressor Controllability Modulates Stress-induced Serotonin but Not Dopamine Efflux in the Nucleus Accumbens Shell on EtoBox?

Stressor Controllability Modulates Stress-induced Serotonin but Not Dopamine Efflux in the Nucleus Accumbens Shell by Sondra T. Bland; Carin Twining; Linda R. Watkins; Steven F. Maier is a Neuroscience article available to read on EtoBox.

What is Stressor Controllability Modulates Stress-induced Serotonin but Not Dopamine Efflux in the Nucleus Accumbens Shell about?

## Abstract The ability of an organism to control a stressor can modulate many of the consequences of stress. Previous research indicates that uncontrollable stress (inescapable shock, IS) activates serotonergic (5‐HT) neurons of the dorsal raphe nucleus (DRN) to a greater degree than controllable stress (escapable shock, ES), potentiating 5‐HT efflux in the DRN and in target regions. Previous research also indicates that IS selectively affects dopamine (DA) efflux. The present study measured 5‐HT and DA efflux in the NAc shell during IS or ES using __in vivo__ microdialysis. Male Sprague Dawley rats with probes in the NAc shell were dialysed while subjected to 100 1.0 mA tailshocks. Rats were run in yoked pairs in wheel‐turn boxes such that one rat (ES) in the pair could terminate the shock received by both himself and his yoked (IS) partner by a behavioral response. No stress controls remained in the dialysis bowls. 5‐HT efflux selectively increased during IS, and remained increased throughout as well as after the stress session. There was no effect of stress on DA efflux. These results indicate that the NAc 5‐HT response is preferentially sensitive to stress and can be modulated

Who reads Stressor Controllability Modulates Stress-induced Serotonin but Not Dopamine Efflux in the Nucleus Accumbens Shell?

Author

Sondra T. Bland; Carin Twining; Linda R. Watkins; Steven F. Maier

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0887-4476)

Published

2003

Language

EN

Field

Neuroscience (Life Sciences)