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Design, Synthesis, Biological and in Silico Evaluation of Coumarin-hydrazone Derivatives as Tubulin Targeted Antiproliferative Agents by Pilli Govindaiah; Naresh Dumala; Irshad Mattan; Paramjit Grover; M. Jaya Prakash is a Chemistry article available to read on EtoBox.

What is Design, Synthesis, Biological and in Silico Evaluation of Coumarin-hydrazone Derivatives as Tubulin Targeted Antiproliferative Agents about?

Coumarin-based different series of hydrazone derivatives were synthesized and evaluated for anticancer activity against four different human cancer cell lines. The activity of the compounds were compared with doxorubicin as a standard drug and all the compounds exhibited good to moderate cytotoxicity with IC values ranging from 6.07 to 60.45 μM against all the examined cancer cell lines. Based on the screening results, it was concluded that the compounds 12a and 18a were the most promising medicinal entities. In vitro tubulin polymerisation inhibition assay was performed for the compounds 12a and 18a and these two compounds displayed good potency when compared with colchicine as the standard drug. The interaction of these compounds with tubulin protein was also studied with the help of molecular docking technique using Discovery studio software. Furthermore, the molecular and ADMET properties of the compounds were computed with Osiris property software and PreADMET server. The compounds exhibited exciting in vitro and in silico results. Hence we propose that the compounds 12a and 18a could be developed as tubulin targeted potential antiproliferative agents.

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Author

Pilli Govindaiah; Naresh Dumala; Irshad Mattan; Paramjit Grover; M. Jaya Prakash

Published

2019

Language

EN

Field

Chemistry (Physical Sciences)