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Efficacy and safety of intravenous lidocaine in propofol-based sedation for ERCP procedures: a prospective, randomized, double-blinded, controlled trial by Liu, Jing; Liu, Xiaoping; Peng, Li-ping; Ji, Rui; Liu, Chao; Li, Yan-Qing is a Medicine article available to read on EtoBox.

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## Background and aims: Propofol-based sedation is widely used in ercp procedures, but adverse respiratory or cardiovascular events commonly occur. intravenous injection of lidocaine has an analgesic effect and can reduce the requirements of fentanyl and propofol during abdominal surgery. the objective of this study was to assess the efficacy and safety of intravenous lidocaine on propofol requirements during ercp procedures. ## Methods: Forty-eight patients scheduled for ercp were randomly divided into 2 groups, the lidocaine group and the control group. all patients received .02 mg/kg midazolam and .1 μg/kg sufentanil intravenously as premedication. a bolus of propofol was applied for induction of sedation, and perfusion of propofol was applied for maintenance. patients in the lidocaine group received a bolus of 1.5 mg/kg lidocaine intravenously followed by continuous infusion of 2 mg/kg/h, whereas the control group received the same volumes of saline solution. the primary outcome was the propofol requirement during ercp. ## Results: Compared with the control group, propofol requirements were reduced by 33.8% in the lidocaine group (212.0 ± 118.2 mg vs 320.0 ± 189.6 mg, p = .023)

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Author

Liu, Jing; Liu, Xiaoping; Peng, Li-ping; Ji, Rui; Liu, Chao; Li, Yan-Qing

Publisher

Elsevier Science; Elsevier ; Mosby Inc.; Elsevier BV (ISSN 1097-6779)

Published

2020

Language

EN

Field

Medicine (Health Sciences)