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Cost-effective analysis of transcatheter aortic valve replacement in patients with severe symptomatic aortic stenosis: A prospective multicenter study by Makoto Amaki; Kensuke Moriwaki; Michikazu Nakai; Tetsuhiro Yamano; Atsushi Okada; Hideaki Kanzaki; Masaki Izumo; Hiroki Usuku; Tetsuari Onishi; Toshiyuki Nagai; Yoshihiro Miyamoto; Tomoyuki Fujita; Hiroya Kawai; Yoshihiro Akashi; Kenichi Tsujita; Satoaki Matoba; Junjiro Kobayashi; Chisato Izumi; Toshihisa Anzai is a Medicine article available to read on EtoBox.

What is Cost-effective analysis of transcatheter aortic valve replacement in patients with severe symptomatic aortic stenosis: A prospective multicenter study about?

Background: Transcatheter aortic valve replacement (TAVR) for severe symptomatic aortic stenosis (AS) does not benefit all patients. We performed a prospective multicenter study to investigate the cost-effectiveness of TAVR in a Japanese cohort. Methods and results: We prospectively enrolled 110 symptomatic patients with severe AS who underwent TAVR from five institutions. The quality of life measurement (QOL) was performed for each patient before and at 6 months after TAVR. Patients without an improvement in QOL at 6 months after TAVR were defined as non-responders. Pre-TAVR higher QOL, higher clinical frailty scale predicted the non-responders. Three models, 1) conservative treatment for all patients strategy, 2) TAVR for all patients strategy, and 3) TAVR for a selected patient strategy who is expected to be a responder, were simulated. Lifetime cost-effectiveness was estimated using incremental cost-effectiveness ratio (ICER) and cost per quality-adjusted life-year (QALY) gained. In comparison to conservative therapy for all patients, ICER was estimated to be 5,765,800 yen/QALY for TAVR for all patients and 2,342,175 yen/QALY for TAVR for selected patient strategy patients, whi

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Author

Makoto Amaki; Kensuke Moriwaki; Michikazu Nakai; Tetsuhiro Yamano; Atsushi Okada; Hideaki Kanzaki; Masaki Izumo; Hiroki Usuku; Tetsuari Onishi; Toshiyuki Nagai; Yoshihiro Miyamoto; Tomoyuki Fujita; Hiroya Kawai; Yoshihiro Akashi; Kenichi Tsujita; Satoaki Matoba; Junjiro Kobayashi; Chisato Izumi; Toshihisa Anzai

Publisher

Elsevier BV

Published

2024

Language

EN

Field

Medicine (Health Sciences)