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Can I read CD5 Gene Signature Identifies Diffuse Large B-Cell Lymphomas Sensitive to Brutonʼs Tyrosine Kinase Inhibition on EtoBox?
CD5 Gene Signature Identifies Diffuse Large B-Cell Lymphomas Sensitive to Brutonʼs Tyrosine Kinase Inhibition by Alan Cooper; Sravya Tumuluru; Kyle Kissick; Girish Venkataraman; Joo Y. Song; Andrew Lytle; Gerben Duns; Jovian Yu; Nikita Kotlov; Aleksander Bagaev; Brendan Hodkinson; Srimathi Srinivasan; Sonali M. Smith; David W. Scott; Christian Steidl; James K. Godfrey; Justin Kline is a Medicine article available to read on EtoBox.
What is CD5 Gene Signature Identifies Diffuse Large B-Cell Lymphomas Sensitive to Brutonʼs Tyrosine Kinase Inhibition about?
## PURPOSE A genetic classifier termed LymphGen accurately identifies diffuse large B-cell lymphoma (DLBCL) subtypes vulnerable to Bruton's tyrosine kinase inhibitors (BTKis), but is challenging to implement in the clinic and fails to capture all DLBCLs that benefit from BTKi-based therapy. Here, we developed a novel CD5 gene expression signature as a biomarker of response to BTKi-based therapy in DLBCL. ## METHODS CD5 immunohistochemistry (IHC) was performed on 404 DLBCLs to identify CD5 IHC+ and CD5 IHC– cases, which were subsequently characterized at the molecular level through mutational and transcriptional analyses. A 60-gene CD5 gene expression signature (CD5sig) was constructed using genes differentially expressed between CD5 IHC+ and CD5 IHC– non–germinal center B-cell-like (non-GCB DLBCL) DLBCLs. This CD5sig was applied to external DLBCL data sets, including pretreatment biopsies from patients enrolled in the PHOENIX study (n = 584) to define the extent to which the CD5sig could identify non-GCB DLBCLs that benefited from the addition of ibrutinib to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). ## RESULTS CD5 expression was observed in 12
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- Author
- Alan Cooper; Sravya Tumuluru; Kyle Kissick; Girish Venkataraman; Joo Y. Song; Andrew Lytle; Gerben Duns; Jovian Yu; Nikita Kotlov; Aleksander Bagaev; Brendan Hodkinson; Srimathi Srinivasan; Sonali M. Smith; David W. Scott; Christian Steidl; James K. Godfrey; Justin Kline
- Publisher
- American Society of Clinical Oncology (ASCO)
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)