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Sub-cellular internalization and organ specific oral elivery of PABA nanoparticles by side chain variation by Jhillu S Yadav; Pragna P Das; T Lakshminarayan Reddy; Indira Bag; Priyadarshini M Lavanya; Bulusu Jagannadh; Debendra K Mohapatra; Manika Pal Bhadra; Utpal Bhadra is a Engineering article available to read on EtoBox.

What is Sub-cellular internalization and organ specific oral elivery of PABA nanoparticles by side chain variation about?

## Background Organic nanomaterials having specific biological properties play important roles in __in vivo__ delivery and clearance from the live cells. To develop orally deliverable nanomaterials for different biological applications, we have synthesized several fluorescently labelled, self-assembled PABA nanoparticles using possible acid side chain combinations and tested against insect and human cell lines and __in vivo__ animal model. Flurophores attached to nanostructures help in rapid __in vivo__ screening and tracking through complex tissues. The sub-cellular internalization mechanism of the conjugates was determined. A set of physio-chemical parameters of engineered nanoskeletons were also defined that is critical for preferred uptake in multiple organs of live __Drosophila__. ## Results The variability of side chains alter size, shape and surface texture of each nanomaterial that lead to differential uptake in human and insect cells and to different internal organs in live __Drosophila__ via energy dependent endocytosis. Our results showed that physical and chemical properties of C-11 and C-16 acid chain are best fitted for delivery to complex organs in __Drosophila__. Ho

Who reads Sub-cellular internalization and organ specific oral elivery of PABA nanoparticles by side chain variation?

Author

Jhillu S Yadav; Pragna P Das; T Lakshminarayan Reddy; Indira Bag; Priyadarshini M Lavanya; Bulusu Jagannadh; Debendra K Mohapatra; Manika Pal Bhadra; Utpal Bhadra

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2003-; Springer Science and Business Media LLC (ISSN 1477-3155)

Published

2011

Language

EN

Field

Engineering (Physical Sciences)