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Fluoropolymer-MOF Hybrids with Switchable Hydrophilicity for ^19^F MRI-Monitored Cancer Therapy by Qiaoyun Wang; Ye Yu; Yixin Chang; Xin Xu; Min Wu; Gayathri R. Ediriweera; Hui Peng; Xu Zhen; Xiqun Jiang; Debra J. Searles; Changkui Fu; Andrew K. Whittaker is a scholarly article available to read on EtoBox.

What is Fluoropolymer-MOF Hybrids with Switchable Hydrophilicity for ^19^F MRI-Monitored Cancer Therapy about?

Cancer theranostics that combines cancer diagnosis and therapy is a promising approach for personalized cancer treatment. However, current theranostic strategies suffer from low imaging sensitivity for visualization and an inability to target the diseased tissue site with high specificity, thus hindering their translation to the clinic. In this study, we have developed a tumor microenvironment-responsive hybrid theranostic agent by grafting water-soluble, low-fouling fluoropolymers to pH-responsive zeolitic imidazolate framework-8 (ZIF-8) nanoparticles by surface-initiated RAFT polymerization. The conjugation of the fluoropolymers to ZIF-8 nanoparticles not only allows sensitive in vivo visualization of the nanoparticles by 19 F MRI but also significantly prolongs their circulation time in the bloodstream, resulting in improved delivery efficiency to tumor tissue. The ZIF-8-fluoropolymer nanoparticles can respond to the acidic tumor microenvironment, leading to progressive degradation of the nanoparticles and release of zinc ions as well as encapsulated anticancer drugs. The zinc ions released from the ZIF-8 can further coordinate to the fluoropolymers to switch the hydrophilicity

Author

Qiaoyun Wang; Ye Yu; Yixin Chang; Xin Xu; Min Wu; Gayathri R. Ediriweera; Hui Peng; Xu Zhen; Xiqun Jiang; Debra J. Searles; Changkui Fu; Andrew K. Whittaker

Publisher

American Chemical Society (ACS)

Published

2023

Language

EN