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Anthropometric indicators of adiposity and risk of primary liver cancer: A systematic review and dose–response meta-analysis by Lun-Jie Yan; Long-Shan Yang; Yu-Chuan Yan; Si-Yu Tan; Zi-Niu Ding; Hui Liu; Dong-Xu Wang; Zhao-Ru Dong; Tao Li is a Medicine article available to read on EtoBox.
What is Anthropometric indicators of adiposity and risk of primary liver cancer: A systematic review and dose–response meta-analysis about?
Background and aims Adiposity is associated with an increased risk of primary liver cancer (PLC). As the most commonly used indicator of adiposity, the body mass index (BMI) has been questioned for its limitations in reflecting visceral fat. This study aimed to investigate the role of different anthropometric indicators in identifying the risk of PLC by accounting for potential non-linear associations. Methods Systematic searches were conducted in the PubMed, Embase, Cochrane Library, Sinomed, Web of Science, and CNKI databases. Hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) were used to assess the pooled risk. The dose-response relationship was assessed using a restricted cubic spline model. Results Sixty-nine studies involving more than 30 million participants were included in the final analysis. Regardless of the indicator used, adiposity was strongly associated with an increased risk of PLC. When comparing the HRs per 1-standard deviation increment across indicators of adiposity, the association was strongest for waist-to-height ratio (WHtR) (HR = 1.39), followed by waist-to-hip ratio (WHR) (HR = 1.22), BMI (HR = 1.13), waist circumference (WC) (HR = 1
Who reads Anthropometric indicators of adiposity and risk of primary liver cancer: A systematic review and dose–response meta-analysis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Lun-Jie Yan; Long-Shan Yang; Yu-Chuan Yan; Si-Yu Tan; Zi-Niu Ding; Hui Liu; Dong-Xu Wang; Zhao-Ru Dong; Tao Li
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)