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Can I read Early Inflammatory Signatures Predict Subsequent Cognition in Long-Term Virally Suppressed Women With HIV on EtoBox?
Early Inflammatory Signatures Predict Subsequent Cognition in Long-Term Virally Suppressed Women With HIV by Rubin, Leah H.; Xu, Yanxun; Norris, Philip J.; Wang, Xuzhi; Dastgheyb, Raha; Fitzgerald, Kathryn C.; Keating, Sheila M.; Kaplan, Robert C.; Maki, Pauline M.; Anastos, Kathryn; Springer, Gayle; Benning, Lorie; Kassaye, Seble; Gustafson, Deborah R.; Valcour, Victor G.; Williams, Dionna W. is a Neuroscience article available to read on EtoBox.
What is Early Inflammatory Signatures Predict Subsequent Cognition in Long-Term Virally Suppressed Women With HIV about?
Immunologic function is an important determinant of cognition. Here we examined the contribution of early immune signatures to cognitive performance among HIV-infected, virally suppressed women (HIV+VS) and in HIV-uninfected (HIV-) women. Specifically, we measured serum inflammatory markers, developed combinatory immune signatures, and evaluated their associations with cognition. Forty-nine HIV+VS women in the Women’s Interagency HIV Study (WIHS) who achieved viral suppression shortly after effective antiretroviral therapy (ART) initiation, and 56 matched HIV− women were selected. Forty-two serum inflammatory markers were measured within 2 years of effective ART initiation for HIV+VS women, and at an initial timepoint for HIV− women. The same inflammatory markers were also measured approximately 1, 7, and 12 years later for all women. Of the 105 women with complete immune data, 83 (34 HIV+VS, 49 HIV−) also had cognitive data available 12 years later at ≥1 time points (median = 3.1). We searched for combinatory immune signatures by adapting a dynamic matrix factorization analytic method that builds upon Tucker decomposition followed by Ingenuity^®^ Pathway Analysis to facilitate dat
Who reads Early Inflammatory Signatures Predict Subsequent Cognition in Long-Term Virally Suppressed Women With HIV?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Rubin, Leah H.; Xu, Yanxun; Norris, Philip J.; Wang, Xuzhi; Dastgheyb, Raha; Fitzgerald, Kathryn C.; Keating, Sheila M.; Kaplan, Robert C.; Maki, Pauline M.; Anastos, Kathryn; Springer, Gayle; Benning, Lorie; Kassaye, Seble; Gustafson, Deborah R.; Valcour, Victor G.; Williams, Dionna W.
- Publisher
- Frontiers; Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2007- (ISSN 1662-5145)
- Published
- 2020
- Language
- EN
- Field
- Neuroscience (Life Sciences)