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Introduction and guidance 11 Introduction and guidance 12 Week 1: A future without antibiotics? 17 Introduction 18 1 Bacteria and infectious disease 20 2 Antibiotics 26 3 Pre-antibiotic era 31 4 Modern times 35 5 Case study: the link between antibiotic use and antibiotic resistance 41 6 What does the future hold? 45 7 This week’s quiz 49 8 Summary 50 Week 2: How do antibiotics work? 51 Introduction 52 1 Selective toxicity 54 2 Antibiotic modes of action 61 3 Case study: mechanism of ß-lactams 69 4 Types of antibiotic 72 5 This week’s quiz 79 6 Summary 80 Week 3: How do bacteria become resistant to antibiotics? 81 Introduction 82 1 Antibiotic resistance mechanisms 83 2 Intrinsic and acquired resistance 91 3 Case study: resistance to third-generation cephalosporins 96 4 This week’s quiz 105 5 Summary 106 Week 4: Why are so many bacteria resistant to antibiotics? 107 Introduction 108 1 How do mutations lead to resistance? 110 2 Horizontal transfer 119 3 Why are so many bacteria resistant to antibiotics? 128 4 Case study: resistance to cephalosporins 136 5 This week’s quiz 144 6 Summary 145 Week 5: How antibiotic resistance has become such a big problem 146 Introduction 147 1 The antib
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- The Open University
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- The Open University
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- EN
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