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Tempol Improves Xanthine Oxidoreductase-mediated Vascular Responses to Nitrite in Experimental Renovascular Hypertension by Oliveira-Paula, Gustavo H.; Pinheiro, Lucas C.; Guimaraes, Danielle A.; Tella, Sandra O. Conde; Blanco, Ana L. Furlan; Angelis, Celio D.; Schechter, Alan N.; Tanus-Santos, Jose E. is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Upregulation of xanthine oxidoreductase (XOR) increases vascular reactive oxygen species (ROS) levels and contributes to nitroso-redox imbalance. However, XOR can generate nitric oxide (NO) from nitrite, and increased superoxide could inactivate NO formed from nitrite. This study tested the hypothesis that XOR contributes to the cardiovascular effects of nitrite in renovascular hypertension, and that treatment with the antioxidant tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) improves XOR-mediated effects of nitrite. Blood pressure was assessed weekly in two-kidney one-clip (2K1C) and control rats. After six weeks of hypertension, the relaxing responses to nitrite were assessed in aortic rings in the presence of the XOR inhibitor oxypurinol (or vehicle), either in the absence or in the presence of tempol. Moreover, __in vivo__ hypotensive responses to nitrite were also examined in the presence of oxypurinol (or vehicle) and tempol (or vehicle). Aortic XOR activity and expression were evaluated by fluorescence and Western blot, respectively. Vascular ROS production was assessed by the dihydroethidium assay. 2K1C hypertensive rats showed increased aortic XOR activity and va

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Author

Oliveira-Paula, Gustavo H.; Pinheiro, Lucas C.; Guimaraes, Danielle A.; Tella, Sandra O. Conde; Blanco, Ana L. Furlan; Angelis, Celio D.; Schechter, Alan N.; Tanus-Santos, Jose E.

Publisher

Elsevier ; Elsevier BV; Amsterdam: Elsevier (ISSN 2213-2317)

Published

2016

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)