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Design, Syntheses and Evaluation of Hemocompatible Pegylated-antimicrobial Polymers with Well-controlled Molecular Structures by Shrinivas Venkataraman; Ying Zhang; Lihong Liu; Yi-Yan Yang is a Engineering article available to read on EtoBox.

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In this paper, we have designed and synthesized well-defined pegylated-polymers with tertiary amines from readily available commodity monomers 2-(dimethylamino)ethyl methacrylate (DMAEMA) and oligo(ethylene glycol) methyl ether methacrylate (OEGMA, M(n) approximately 475 Da) by reversible addition-fragmentation chain transfer (RAFT) polymerisation. By employing a simple and efficient post-polymerisation functionalization strategy, tertiary amines were quaternized to result in cationic polymers. By the careful selection of the functional halide, X-(CH(2))q-R, (where in X=halide; R=the chemical functionality; q=the number of alkyl spacer between the quaternary ammonium group and R), a series of polymers with well-controlled molecular weight, different amphiphilic balance and chemical functionalities (such as alkyl, primary alcohol, primary amine and carboxylic acid) were readily synthesized. The antimicrobial activities of these cationic polymers were determined against Gram-positive bacteria Bacillus subtilis. Minimum inhibitory concentration (MIC), the polymer concentration to completely inhibit the bacterial growth, was found to be dependent both on the nature of functional group

Who reads Design, Syntheses and Evaluation of Hemocompatible Pegylated-antimicrobial Polymers with Well-controlled Molecular Structures?

Author

Shrinivas Venkataraman; Ying Zhang; Lihong Liu; Yi-Yan Yang

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)

Published

2010

Language

EN

Field

Engineering (Physical Sciences)