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What is Apoenzyme and Holoenzyme Chemistry about?

There are two types of enzymes - apo enzymes and holoenzymes. Apo enzymes require cofactors like metals or vitamins to become active, forming holoenzymes. Cofactors attach to the apo enzyme protein to create the catalytically active holoenzyme. DNA polymerase is an example of a holoenzyme, containing protein subunits and a magnesium ion cofactor to catalyze DNA replication. An apo enzyme forms when its cofactor is removed, leaving an inactive protein that can later re-bind its cofactor to regain function.

Author

manahil siddiqui

Language

EN