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ACROSCORE: a new and simple tool for the diagnosis of acromegaly, a rare and underdiagnosed disease by Nunzia Prencipe; Irene Floriani; Federica Guaraldi; Stellina V. Di Giacomo; Salvatore Cannavo; Giorgio Arnaldi; Alessandro Berton; Valter Torri; Maurizio Spinello; Emanuela Arvat; Ezio Ghigo; Silvia Grottoli is a Medicine article available to read on EtoBox.
What is ACROSCORE: a new and simple tool for the diagnosis of acromegaly, a rare and underdiagnosed disease about?
## Summary ## Objective Acromegaly, a disease caused by GH/IGF‐I hypersecretion, is associated with a high mortality rate; early recognition is therefore necessary to ensure successful treatment and to avoid comorbidities. We have created a symptom/sign scoring tool (ACROSCORE) for physicians to use to identify acromegaly. ## Design To compare cases of acromegaly diagnosed between 1990 and 2014 against a control group affected by non‐GH‐secreting pituitary tumours to identify symptoms and signs that are most discriminative for acromegaly. ## Patients Confirmed acromegaly patients and patients affected by non‐GH‐secreting pituitary tumours. ## Measurements In all patients, signs, symptoms and comorbidities were recorded from medical records and collected using a specifically designed questionnaire. ## Results A total of 194 acromegaly patients [115 women; mean (SD) age 47·2 (14·2) years] and 243 patients affected by non‐GH‐secreting pituitary tumours [131 women; mean (SD) age 45·8 (15·8) years] were included. A strong association was observed for type 2/secondary diabetes [odds ratio (OR) 3·7], hyperhidrosis (OR 6·1), thyroid hyperplasia (OR 13·9), colorectal polyps (OR 10·4), space
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- Author
- Nunzia Prencipe; Irene Floriani; Federica Guaraldi; Stellina V. Di Giacomo; Salvatore Cannavo; Giorgio Arnaldi; Alessandro Berton; Valter Torri; Maurizio Spinello; Emanuela Arvat; Ezio Ghigo; Silvia Grottoli
- Publisher
- Wiley
- Published
- 2015
- Language
- EN
- Field
- Medicine (Health Sciences)