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Lactobacillus plantarum BSGP201683 Improves the Intestinal Barrier of Giant Panda Microbiota-Associated Mouse Infected by Enterotoxigenic Escherichia coli K88 by Zhou, Yi; Ni, Xueqin; Duan, Ling; Niu, Lili; Liu, Qian; Zeng, Yan; Wang, Qiang; Wang, Jie; Khalique, Abdul; Pan, Kangcheng; Jing, Bo; Zeng, Dong is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Lactobacillus plantarum BSGP201683 Improves the Intestinal Barrier of Giant Panda Microbiota-Associated Mouse Infected by Enterotoxigenic Escherichia coli K88 about?

Giant pandas often suffered from gastrointestinal disease, especially the captive sub-adult one. Our study aims to investigate whether L. plantarum G83, a good panda-derived probiotic, can improve the intestinal barrier against the enterotoxigenic Escherichia coli K88 (E. coli K88) infection in giant panda microbiota-associated mice (GPAM). We treated SPF mice with antibiotics cocktail and transplanted the giant panda intestinal microbiota to set up a GPAM. Our results demonstrated that the microbiota of GPAM changed over time and was relatively stable in the short-term experiment (2-4 weeks). Whereafter, the GPAM pretreated with L. plantarum G83 for 15 days and infected with enterotoxigenic E. coli K88. The result indicated that the number of Bifidobacteria spp. increased in GPAM-G and GPAM-GE groups; the Lactobacillus spp. only increased in the GPAM-G group. Although the abundance of Enterobacteriaceae spp. only decreased in the GPAM-G group, the copy number of Escherichia coli in the GPAM-E group was significantly lower than that in the other groups. Meanwhile, the L. plantarum G83-induced alteration of microbiota could increase the mRNA expression of Claudin-1, Zo-1, and Occlud

Who reads Lactobacillus plantarum BSGP201683 Improves the Intestinal Barrier of Giant Panda Microbiota-Associated Mouse Infected by Enterotoxigenic Escherichia coli K88?

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Author
Zhou, Yi; Ni, Xueqin; Duan, Ling; Niu, Lili; Liu, Qian; Zeng, Yan; Wang, Qiang; Wang, Jie; Khalique, Abdul; Pan, Kangcheng; Jing, Bo; Zeng, Dong
Publisher
Springer-Verlag; Springer New York LLC; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1867-1306)
Published
2020
Language
EN
Field
Agricultural and Biological Sciences (Life Sciences)

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