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Immune Checkpoint Molecules—Inherited Variations as Markers for Cancer Risk by Marta Wagner; Monika Jasek; Lidia Karabon is a scholarly article available to read on EtoBox.

What is Immune Checkpoint Molecules—Inherited Variations as Markers for Cancer Risk about?

In recent years, immunotherapy has been revolutionized by a new approach that works by blocking receptors called immune checkpoints (IC). These molecules play a key role in maintaining immune homeostasis, mainly by suppressing the immune response and by preventing its overactivation. Since inhibition of the immune response by IC can be used by cancer to avoid recognition and destruction by immune system, blocking them enhances the anti-tumor response. This therapeutic approach has brought spectacular clinical effects. The ICs present heterogeneous expression patterns on immune cells, which may affect the effectiveness of immunotherapy. The inherited genetic variants in regulatory regions of ICs genes can be considered as potential factors responsible for observed inter-individual differences in ICs expression levels on immune cells. Additionally, polymorphism located in exons may introduce changes to ICs amino acid sequences with potential impact on functional properties of these molecules. Since genetic variants may affect both expression and structure of ICs, they are considered as risk factors of cancer development. Inherited genetic markers such as SNPs may also be useful in st

Author

Marta Wagner; Monika Jasek; Lidia Karabon

Publisher

Frontiers Media SA

Published

2021

Language

EN