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Can I read In Vitro Resistance To Cytosine Arabinoside, Not To Daunorubicin, Is Associated With The Risk Of Relapse In De Novo Acute Myeloid Leukaemia on EtoBox?
In Vitro Resistance To Cytosine Arabinoside, Not To Daunorubicin, Is Associated With The Risk Of Relapse In De Novo Acute Myeloid Leukaemia by Edwin Klumper; Gert J. Ossenkoppele; Rob Pieters; Dieuwke R. Huismans; Annemarie H. Loonen; Antoinette Rottier; Guus Westra; Anjo J. P. Veerman is a Medicine article available to read on EtoBox.
What is In Vitro Resistance To Cytosine Arabinoside, Not To Daunorubicin, Is Associated With The Risk Of Relapse In De Novo Acute Myeloid Leukaemia about?
The efficacy of chemotherapy in acute myeloid leukaemia (AML) is limited by clinical drug resistance. We determined __in vitro__ resistance to cytosine arabinoside (ARA‐C), daunorubicin (DNR), mitoxantrone (MITOX), m‐amsacrine (AMSA) and etoposide (VP16) in 49 adults with __de novo__ AML using the MTT assay. Results showed that non‐ responders to chemotherapy were, __in vitro__, 2.9‐fold more resistant to DNR, but not more resistant to ARA‐C, compared to complete responders. However, complete responders who were __in vitro__ resistant to ARA‐C had a 4‐fold higher risk of relapse (95% CI 1.3–12.5‐fold) compared to complete responders __in vitro__ sensitive to ARA‐C. With a mean follow‐up of 12 months the probability of continuous complete remission (CCR) for patients __in vitro__ sensitive to ARA‐C was 61% at 34 months (95% CI 28–82%), whereas all patients __in vitro__ resistant to ARA‐C relapsed within 18 months from diagnosis. This difference appeared to be independent of other clinical features such as sex, age, white blood cell count, FAB classification, and CD34 expression. __In vitro__ resistance to DNR was not related to the probability of CCR. We conclude that __in vitro__ d
Who reads In Vitro Resistance To Cytosine Arabinoside, Not To Daunorubicin, Is Associated With The Risk Of Relapse In De Novo Acute Myeloid Leukaemia?
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- Author
- Edwin Klumper; Gert J. Ossenkoppele; Rob Pieters; Dieuwke R. Huismans; Annemarie H. Loonen; Antoinette Rottier; Guus Westra; Anjo J. P. Veerman
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 1996
- Language
- EN
- Field
- Medicine (Health Sciences)