Opening book details…
Can I read Insights from Mouse Models Into Human Retinoblastoma on EtoBox?
Insights from Mouse Models Into Human Retinoblastoma by David MacPherson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Insights from Mouse Models Into Human Retinoblastoma about?
Novel murine models of retinoblastoma based on __Rb__ gene deletion in concert with inactivation of __Rb__ family members have recently been developed. These new __Rb__ knockout models of retinoblastoma provide excellent tools for pre-clinical studies and for the exploration of the genetics of tumorigenesis driven by __RB__ inactivation. This review focuses on the developmental consequences of __Rb__ deletion in the retina and the genetic interactions between __Rb__ and the two other members of the pocket protein family, p107 (__Rbl1__) and p130 (__Rbl2__). There is increasing appreciation that homozygous __RB__ mutations are insufficient for human retinoblastoma. Identifying and understanding secondary gene alterations that cooperate with __RB__ inactivation in tumorigenesis may be facilitated by mouse models. Recent investigation of the __p53__ pathway in retinoblastoma, and evidence of spatial topology to early murine retinoblastoma are also discussed in this review.
Who reads Insights from Mouse Models Into Human Retinoblastoma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- David MacPherson
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2006-; Springer Science and Business Media LLC (ISSN 1747-1028)
- Published
- 2008
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)