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Details and outcomes of a large cohort of MOG-IgG associated optic neuritis by John J. Chen; Eoin P. Flanagan; M. Tariq Bhatti; Nanthaya Tisavipat; Sepideh Jamali; Amy Kunchok; Eric R. Eggenberger; Marie Di Nome; Elias S. Sotirchos; Eleni S. Vasileiou; Amanda D. Henderson; Anthony C. Arnold; Laura Bonelli; Nicolas Seleme; Alvaro J. Mejia-Vergara; Heather E. Moss; Tanyatuth Padungkiatsagul; Hadas Stiebel-Kalish; Itay Lotan; Adi Wilf-Yarkoni; Mark A. Hellmann; Amrita Vuppala; David Hodge; Sean J. Pittock is a Medicine article available to read on EtoBox.
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## Background: The goal of this study was to examine the temporal relationship of eye pain to visual loss and investigate whether timing of steroid treatment affects the rate and extent of visual recovery in optic neuritis (on) from mog-igg associated disease (mogad) in a large cohort of mogad patients with on. ## Methods: This is a multicenter, retrospective cohort study of consecutive mogad patients with on attacks seen from 2017 to 2021 fulfilling the following criteria: (1) clinical history of on; (2) mog-igg seropositivity. on attacks were evaluated for presence/duration of eye pain, nadir of vision loss, time to intravenous methylprednisolone (ivmp) treatment, time to recovery, and final visual outcomes. ## Results: There were 107 patients with 140 attacks treated with ivmp and details on timing of treatment and outcomes. eye pain was present in 125/140 (89%) attacks with pain onset a median of 3 days (range, 0 to 20) prior to vision loss. among 46 on attacks treated with ivmp within 2 days of onset of vision loss, median time to recovery was 4 days (range, 0 to 103) compared to 15 days (range, 0 to 365) in 94 on attacks treated after 2 days (p = 0.004). those treated within
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- Author
- John J. Chen; Eoin P. Flanagan; M. Tariq Bhatti; Nanthaya Tisavipat; Sepideh Jamali; Amy Kunchok; Eric R. Eggenberger; Marie Di Nome; Elias S. Sotirchos; Eleni S. Vasileiou; Amanda D. Henderson; Anthony C. Arnold; Laura Bonelli; Nicolas Seleme; Alvaro J. Mejia-Vergara; Heather E. Moss; Tanyatuth Padungkiatsagul; Hadas Stiebel-Kalish; Itay Lotan; Adi Wilf-Yarkoni; Mark A. Hellmann; Amrita Vuppala; David Hodge; Sean J. Pittock
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)