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Generation and Fates of Supernumerary Centrioles in Dividing Cells by Byungho Shin; Myung Se Kim; Yejoo Lee; Gee In Jung; Kunsoo Rhee is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Generation and Fates of Supernumerary Centrioles in Dividing Cells about?

The centrosome is a subcellular organelle from which a cilium assembles. Since centrosomes function as spindle poles during mitosis, they have to be present as a pair in a cell. How the correct number of centrosomes is maintained in a cell has been a major issue in the fields of cell cycle and cancer biology. Centrioles, the core of centrosomes, assemble and segregate in close connection to the cell cycle. Abnormalities in centriole numbers are attributed to decoupling from cell cycle regulation. Interestingly, supernumerary centrioles are commonly observed in cancer cells. In this review, we discuss how supernumerary centrioles are generated in diverse cellular conditions. We also discuss how the cells cope with supernumerary centrioles during the cell cycle.

Who reads Generation and Fates of Supernumerary Centrioles in Dividing Cells?

Author

Byungho Shin; Myung Se Kim; Yejoo Lee; Gee In Jung; Kunsoo Rhee

Publisher

Korean Society for Molecular and Cellular Biology

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)