Can I read Hyaluronan-estradiol nanogels as potential drug carriers to target ER+ breast cancer cell line on EtoBox?
Hyaluronan-estradiol nanogels as potential drug carriers to target ER+ breast cancer cell line by L. Paoletti; N. Zoratto; M. Benvenuto; D. Nardozi; V. Angiolini; P. Mancini; L. Masuelli; R. Bei; G.V. Frajese; P. Matricardi; M. Nalli; C. Di Meo is a Materials Science article available to read on EtoBox.
What is Hyaluronan-estradiol nanogels as potential drug carriers to target ER+ breast cancer cell line about?
An innovative hyaluronan-based nano-delivery system is proposed for the active targeting towards ER+ breast cancer. Hyaluronic acid (HA), an endogenous and bioactive anionic polysaccharide, is functionalized with estradiol (ES), a sexual hormone involved in the development of some hormone-dependent tumors, to give an amphiphilic derivative (HA-ES) able to spontaneously self-assemble in water to form soft nanoparticles or nanogels (NHs). The synthetic strategy used to obtain the polymer derivatives and the physico-chemical properties of the obtained nanogels (ES-NHs) are reported. ES-NHs ability to entrap hydrophobic molecules has also been investigated, by loading curcumin (CUR) and docetaxel (DTX), both able to inhibit the growth of ER+ breast cancer. The formulations are studied for their capability to inhibit the growth of the MCF-7 cell line, thus evaluating their efficacy and potential as a selective drug delivery systems. Our results demonstrate that ES-NHs have not toxic effects on the cell line, and that both ES-NHs/CUR and ES-NHs/DTX treatments inhibit MCF-7 cell growth, with ES-NHs/DTX effect higher than that of free DTX. Our findings support the use of ES-NHs to deliver
Who reads Hyaluronan-estradiol nanogels as potential drug carriers to target ER+ breast cancer cell line?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- L. Paoletti; N. Zoratto; M. Benvenuto; D. Nardozi; V. Angiolini; P. Mancini; L. Masuelli; R. Bei; G.V. Frajese; P. Matricardi; M. Nalli; C. Di Meo
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Materials Science (Physical Sciences)