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Developmental Mechanism and Evolutionary Origin of Vertebrate Left/right Asymmetries by Jonathan Cooke is a Environmental Science article available to read on EtoBox.

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## ABSTRACT The systematically ‘handed’, or directionally asymmetrical way in which the major viscera are packed within the vertebrate body is known as __situs__. Other less obvious vertebrate lateralisations concern cognitive neural function, and include the human phenomena of hand‐use preference and language‐associated cognitive partitioning. An overview, rather than an exhaustive scholarly review, is given of recent advances in molecular understanding of the mechanism that ensures normal development of‘correct’__situs__. While the asymmetry itself and its left/right direction are clearly vertebrate‐conserved characters, data available from various embryo types are compared in order to assess the likelihood that the developmental mechanism is evolutionarily conserved in its entirety. A conserved post‐gastrular‘phylotypic’ stage, with left‐ and right‐specific cascades of key, orthologous gene expressions, clearly exists. It now seems probable that earlier steps, in which symmetry‐breaking information is reliably transduced to trigger these cascades on the correct sides, are also conserved at depth although it remains unclear exactly how these steps operate. Earlier data indicated

Who reads Developmental Mechanism and Evolutionary Origin of Vertebrate Left/right Asymmetries?

Author

Jonathan Cooke

Publisher

Cambridge University Press; Wiley (Blackwell Publishing); John Wiley & Sons Inc.; Wiley (ISSN 1464-7931)

Published

2004

Language

EN

Field

Environmental Science (Life Sciences)