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Intrahepatic TLR3 and IFNL3 Expressions Are Associated with Stages of Fibrosis in Chronic Hepatitis C by Guedes de Sá, Keyla Santos (author);Amoras, Ednelza da Silva Graça (author);Conde, Simone Regina Souza da Silva (author);Queiroz, Maria Alice Freitas (author);Cayres-Vallinoto, Izaura Maria Vieira (author);Ishak, Ricardo (author);Vallinoto, Antonio Carlos Rosário (author) is a Medicine article available to read on EtoBox.
What is Intrahepatic TLR3 and IFNL3 Expressions Are Associated with Stages of Fibrosis in Chronic Hepatitis C about?
An inefficient immune response against the hepatitis C virus (HCV), combined with viral evasion mechanisms, is responsible for the chronicity of infection. The need to evaluate the innate mechanisms of the immune response, such as TLR3 and IFN-λ3, and their relationship with the virus–host interaction is important for understanding the pathogenesis of chronic hepatitis C. The present study aimed to investigate the gene expressions of __TRL3__ and __IFNL3__ in liver tissue, seeking to evaluate whether these could be potential biomarkers of HCV infection. A total of 23 liver biopsy samples were collected from patients with chronic HCV, and 8 biopsies were collected from healthy control patients. RNA extraction, reverse transcription and qPCR were performed to quantify the relative gene expressions of __TLR3__ and __IFNL3__. Data on the viral load; AST, ALT, GGT and AFP levels; and the viral genotype were collected from the patients′ medical records. The intrahepatic expression of __TLR3__ (__p__ = 0.0326) was higher in chronic HCV carriers than in the control group, and the expression of __IFNL3__ (__p__ = 0.0037) was lower in chronic HCV carriers than in the healthy control group. T
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- Author
- Guedes de Sá, Keyla Santos (author);Amoras, Ednelza da Silva Graça (author);Conde, Simone Regina Souza da Silva (author);Queiroz, Maria Alice Freitas (author);Cayres-Vallinoto, Izaura Maria Vieira (author);Ishak, Ricardo (author);Vallinoto, Antonio Carlos Rosário (author)
- Publisher
- MDPI AG
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)