Opening book details…
Can I read Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression on EtoBox?
Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression by Amina Boussouar; Antonin Tortereau; Ambroise Manceau; Andrea Paradisi; Nicolas Gadot; Jonathan Vial; David Neves; Lionel Larue; Maxime Battistella; Christophe Leboeuf; Celeste Lebbé; Anne Janin; Patrick Mehlen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression about?
## Abstract ## Deleted in colorectal cancer (DCC), the receptor for the multifunctional cue netrin-1, acts as a tumor suppressor in intestinal cancer and lung metastasis by triggering cancer cell death when netrin-1 is lowly expressed. Recent genomic data highlighted that DCC is the third most frequently mutated gene in melanoma; we therefore investigated whether DCC could act as a melanoma tumor suppressor. Reexpressing DCC in human melanoma cell lines promoted tumor cell death and tumor growth inhibition in xenograft mouse models. Genetic silencing of DCC prodeath activity in a BRAFV600E mouse model increased the proportion of mice with melanoma, further supporting that DCC is a melanoma tumor suppressor. Netrin-1 expression was elevated in melanoma compared with benign melanocytic lesions. Upregulation of netrin-1 in the skin cells of a BRAFV600E-mutated murine model reduced cancer cell death and promoted melanoma progression. Therapeutic antibody blockade of netrin-1 combined with dacarbazine increased overall survival in several mouse melanoma models. Together, these data support that interfering with netrin-1 could be a viable therapeutic approach in patients with netrin-1–ex
Who reads Netrin-1 and Its Receptor DCC Are Causally Implicated in Melanoma Progression?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Amina Boussouar; Antonin Tortereau; Ambroise Manceau; Andrea Paradisi; Nicolas Gadot; Jonathan Vial; David Neves; Lionel Larue; Maxime Battistella; Christophe Leboeuf; Celeste Lebbé; Anne Janin; Patrick Mehlen
- Publisher
- American Association for Cancer Research; American Association for Cancer Research Inc.; American Association for Cancer Research (AACR) (ISSN 0008-5472)
- Published
- 2019
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)