Can I read HMGA1 and HMGA2 rearrangements in mass‐forming endometriosis on EtoBox?

HMGA1 and HMGA2 rearrangements in mass‐forming endometriosis by Fabiola Medeiros; Ana R. Araujo; Michele R. Erickson‐Johnson; Purna C. Kashyap; Paola Dal Cin; Marisa Nucci; Xiaoke Wang; Debra A. Bell; Andre M. Oliveira is a Medicine article available to read on EtoBox.

What is HMGA1 and HMGA2 rearrangements in mass‐forming endometriosis about?

## Abstract Endometriosis is a common gynecologic disorder characterized by ectopic endometrium associated with pelvic pain and infertility. The pathogenesis of endometriosis is unclear, and several genetic, endocrine, immune, and environmental agents have been studied as putative causative factors. However, consistent somatic genetic alterations have not been identified. Rarely, endometriosis presents as a mass lesion with an infiltrative pattern reminiscent of malignancy. We describe cytogenetic and molecular cytogenetic findings of mass‐forming endometriosis. The index case of pulmonary endometriosis underwent conventional and molecular cytogenetics analysis. In addition, 16 cases of mass‐forming endometriosis, 11 cases of usual endometriosis, and six endometriomas were investigated by fluorescence in situ hybridization (FISH) for __HMGA1__ and __HMGA2__ loci, performed on paraffin‐embedded thin tissue sections with custom‐designed probes. The index patient had an endometriotic lung nodule, with a 46,XX, t(5;6)(q13;p21) karyotype and __HMGA1__ rearrangement by FISH. A second patient had decidualized endometriosis forming a large abdominal mass and __HMGA1__ rearrangement by FISH

Who reads HMGA1 and HMGA2 rearrangements in mass‐forming endometriosis?

Author

Fabiola Medeiros; Ana R. Araujo; Michele R. Erickson‐Johnson; Purna C. Kashyap; Paola Dal Cin; Marisa Nucci; Xiaoke Wang; Debra A. Bell; Andre M. Oliveira

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 1045-2257)

Published

2010

Language

EN

Field

Medicine (Life Sciences)