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Can I read Endocrine and Local IGF-I in the Bony Fish Immune System on EtoBox?
Endocrine and Local IGF-I in the Bony Fish Immune System by Anne-Constance Franz; Oliver Faass; Bernd Köllner; Natallia Shved; Karl Link; Ayako Casanova; Michael Wenger; Helena D’Cotta; Jean-François Baroiller; Oliver Ullrich; Manfred Reinecke; Elisabeth Eppler is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Endocrine and Local IGF-I in the Bony Fish Immune System about?
A role for GH and IGF-I in the modulation of the immune system has been under discussion for decades. Generally, GH is considered a stimulator of innate immune parameters in mammals and teleost fish. The stimulatory effects in humans as well as in bony fish often appear to be correlated with elevated endocrine IGF-I (liver-derived), which has also been shown to be suppressed during infection in some studies. Nevertheless, data are still fragmentary. Some studies point to an important role of GH and IGF-I particularly during immune organ development and constitution. Even less is known about the potential relevance of local (autocrine/paracrine) IGF-I within adult and developing immune organs, and the distinct localization of IGF-I in immune cells and tissues of mammals and fish has not been systematically defined. Thus far, IGF-I has been localized in different mammalian immune cell types, particularly macrophages and granulocytes, and in supporting cells, but not in T-lymphocytes. In the present study, we detected IGF-I in phagocytic cells isolated from rainbow trout head kidney and, in contrast to some findings in mammals, in T-cells of a channel catfish cell line. Thus, although
Who reads Endocrine and Local IGF-I in the Bony Fish Immune System?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Anne-Constance Franz; Oliver Faass; Bernd Köllner; Natallia Shved; Karl Link; Ayako Casanova; Michael Wenger; Helena D’Cotta; Jean-François Baroiller; Oliver Ullrich; Manfred Reinecke; Elisabeth Eppler
- Published
- 2016
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)